Biotech

Gsk acquires Rapt Therapeutics for $2.2 billion

The British pharmaceutical group will pay $58 per share, representing a 65% premium over Monday's $35.10 stock market close

by Mo.D.

REUTERS/Hannah McKay/File Photo

2' min read

Translated by AI
Versione italiana

2' min read

Translated by AI
Versione italiana

Biotechs are coveted by big pharma and remain a field of conquest. The latest announcement is that of GlaxoSmithKline, which has taken over Rapt Therapeutics, a US biotech engaged in the development of therapies for patients suffering from inflammatory and immunological diseases, in a deal worth a total of$2.2 billion. In detail, the British pharmaceutical group will pay $58 per share, a 65% premium over Rapt Therapeutics' closing of $35.10 on Monday.

The deal includes the acquisition of ozureprubart, a potential prophylactic treatment for food allergies that would require a lower frequency of administration than the current standard of care. Gsk clarified that the deal will grant it global rights to the ozureprubart programme, with the exclusion of China.

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Following the announcement yesterday, Gsk shares on the London Stock Exchange closed down around 2%. However, the group's shares are coming off a positive 2025, up around 36% in 2025. The stock of Californian Rapt Therapeutics, on the other hand, jumped about 63% to $57.50 per share, matching the price of the deal.

A pipeline of doubts

Luke Miels, who took over the helm of Gsk at the beginning of the year, will now have to prove to investors that the pipeline of new drugs will be sufficient to support end-of-decade revenue targets and compensate for the patent expiry of a flagship HIV drug. Under previous CEO Emma Walmsley, the UK group spun off its consumer health division Haleon and strengthened its pipeline through several targeted acquisitions. However, investors remained unconvinced by the potential of the upcoming experimental drugs. The group is also facing pressure on the vaccine business, with lower than expected sales, partly because in the US, Health Secretary Robert F. Kennedy Jr. has promoted sceptical positions on vaccines, influencing key recommendations on routine immunisations.

Growth strategies

Gsk is currently strengthening its focus on two strategic pillars: oncology drugs and innovative therapies in immunology and inflammation. The acquisition in 2024 of Aiolos Bio, engaged in the development of an asthma drug, goes in this direction.

Now the lunge on food allergy therapies, which today involve injections every 2-4 weeks, a particularly onerous regimen, especially for children. Ozureprubart would instead allow administration every 12 weeks. If approved, the drug would compete with Xolair, developed by Genentech and Novartis.

The target market is particularly large in the US, where more than 17 million people suffer from food allergies and more than 1.3 million have severe reactions, Gsk reported. Rapt Therapeutics is also testing ozureprubart in chronic spontaneous urticaria, a condition characterised by the appearance of skin pomphi that persist over time.

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