Pharmaceuticals

Pfizer, for activist fund Starboard destroyed 20 billion in value

Jeffrey Smith's investment firm accuses the group of overpaying for recent acquisitions and low returns on research and development

by Mo.D.

REUTERS/Dado Ruvic/Illustration/File Photo

3' min read

3' min read

Value destruction estimated at $20 billion. This is Starboard Value CEO Jeffrey Smith's rebuttal to Pfizer, accused of failing to build a pipeline of new products. Yesterday, speaking at 13D Monitor's active-passive investor summit, Smith described Pfizer's share price drop after the Covid pandemic as "crazy" and said it was time for the company to "step up accountability". Smith calmly went through his 30 minutes at the New York event, pointing out that Pfizer had committed a series of missteps, including overpaying for acquisitions, failing to live up to new treatments, and generating only a 15% return from research and development spending. A figure that would be lower than that of competing pharmaceutical groups such as Eli Lilly and AbbVie. 'That's the problem,' said Smith, 'the discipline of spending and getting the appropriate return from that spending.

Starboard's investment

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Taking a step back, earlier this month it emerged that Starboard had built a $1 billion position in Pfizer to try to stimulate a turnaround of the pharmaceutical company, which according to the activist fund has mishandled the post-pandemic with expensive deals that have not paid off.

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Under the leadership of current CEO Albert Bourla, Pfizer has undertaken a series of acquisitions worth a total of USD 70 billion in recent years, including the purchase of companies such as Global Blood Therapeutics, specialising in the treatment of sickle cell anaemia, and Seagen, active in the oncology sector. However, a dramatic drop in demand for Covid vaccines and treatments, coupled with increasing competition for some of the pharmaceutical group's key products, meant that Pfizer was struggling to fill the gap, despite the acquisitions. Starboard, in its presentation at Tuesday's conference, highlighted precisely how Pfizer overpaid for acquisitions completed after 2022, based on its own sales targets: 'They have to do something different to ensure a change in the way they allocate capital,' Smith said. 'They can't follow Einstein's definition of insanity and keep doing the same things over and over again.

Smith also recalled that the lead drug from the Global Blood Therapeutics acquisition, for example, was withdrawn from the market due to safety concerns: 'This is a blow to their due diligence.

During the New York event, Smith went on to say that Pfizer has not kept its promises on its experimental weight-loss drugs, initially estimating sales of $10 billion, while the industry is now expected to generate less than $600 million by 2030.

Starboard's strategy seemed at first to count on the support of former Pfizer executives Ian Read and Frank D'Amelio, who could have been part of the change in management desired by the activist fund. The two former managers, however, seem to have changed position and have come out in the open, declaring their support for the company and the current management. In spite of this Starboard is proceeding on the course of change: in an interview with Cnbc, Smith suggested that it might make sense for Pfizer to replace Bourla as CEO. The game, therefore, remains open.

Rsv vaccine approval

Meanwhile, Pfizer cashes in on positive news on the drug approval front. The US Food and Drug Administration has approved Pfizer's Rsv vaccine for the prevention of lower respiratory tract disease caused by Rsv in adults aged 18-59 at increased risk of the disease. Rsv typically causes cold-like symptoms, but it is also a leading cause of pneumonia in young children and the elderly, causing 177,000 hospitalisations and 14,000 deaths in the US each year.

Last June, the US CDC narrowed its recommendation for the use of respiratory syncytial virus vaccines in the elderly this year and dropped its recommendation for adults under 60 years of age. The CDC has now recommended the use of Rsv vaccines in adults aged 75 years and older and in those aged 60-74 years who are at increased risk of severe Rsv disease. So although FDA approval is a necessary step, the CDC must also recommend the injections before they are available for the age group targeted by Pfizer's vaccine.

The approval of the Abrysvo vaccine in adults aged 18 to 59 years was based on the results of a late-stage study in which two doses of the vaccine were tested in immunocompromised adults aged 18 years and older. During the tests, the vaccine was well tolerated and showed a safety profile consistent with the results of other vaccine studies, according to Pfizer. CDC advisors are now expected to discuss Pfizer's data this week, but are not expected to vote on whether to expand the recommendation. Pfizer's vaccine is currently approved for people aged 60 years or older and for women during the middle of the third trimester of pregnancy to protect their babies.


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