The studies

Is a high-protein diet always good for you? No, only if combined with exercise

The problem is not the amount of protein in the diet, but a sedentary lifestyle combined with excessive protein intake

3' min read

Translated by AI
Versione italiana

3' min read

Translated by AI
Versione italiana

Protein bars, meal replacements, yoghurt, drinks: for the past few years, absolutely everything has been labelled ‘high in protein’. And the message conveyed to consumers is simple and reassuring: the more protein you eat, the better you’ll feel. But now, a new, comprehensive review of the scientific literature, recently published in the journal Cell Press Blue, is turning the tables and suggesting that, for a great many people, the truth could be exactly the opposite. It suggests that, for many people, eating less protein could mean living longer.

High-protein diets, ranging from the very ‘extreme’ ones such as the ketogenic and Atkins diets (which drastically reduce carbohydrate intake), to the more ‘moderate’ ones such as the Zone Diet, have been the undisputed ‘fad’ of recent years in the field of weight loss. And various pieces of scientific evidence have supported this trend, particularly in the more ‘prudent’ versions.

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The review published on Cell Press Blue

But this study, the result of a major review of over 350 studies on protein restriction and ageing, seriously calls into question the unshakeable faith in protein. The authors from the University of Wisconsin-Madison, led by Dudley Lamming, have sifted through a vast amount of research, concluding that eating less protein – for those leading a sedentary lifestyle – could improve metabolism, reduce inflammation and cellular damage, and activate biological mechanisms associated with healthier ageing. And in some cases, it may even lead to a longer life.

But this does not mean that protein should be condemned outright. Lamming is categorical on this point: “Protein offers benefits for muscle mass growth and the response to exercise in active individuals. However, as most people are relatively sedentary, many are likely to be consuming more protein than is necessary, and this could have negative consequences for their health.”

You can never have too much protein if you lead a sedentary lifestyle

In short, the problem is not the amount of protein in the diet, but a sedentary lifestyle combined with excessive protein intake. This is a dangerous combination which, according to this review, affects a very large proportion of the population.

Science has long shown that reducing the number of calories consumed each day extends the lifespan of many organisms (from the ‘Nobel worm’, Caenorhabditis elegans, to humans) and reduces the risk of age-related diseases, including cancer. The problem is that it is not easy to follow a significantly low-calorie diet for years on end, because sooner or later the body rebels and triggers defence mechanisms, including uncontrollable hunger. Protein restriction, on the other hand, could offer a viable solution: studies on fruit flies and rodents have shown that those consuming less protein lived longer even without making drastic cuts to their calorie intake. And recent clinical trials have confirmed that people who reduce their protein intake lose weight and body fat and improve their fasting blood glucose levels, often without cutting calories.

FGF21: a new player in metabolism that warrants further study

At the heart of it all is a hormone that is still little understood, but which has interesting effects: FGF21 (fibroblast growth factor 21), the levels of which tend to rise when protein intake is reduced. Studies carried out on mice have shown that animals with higher levels of FGF21 lived longer (particularly the males). In humans, too, eating less protein increases FGF21, with benefits for energy expenditure, blood glucose regulation and inflammation.

Also in the dock are certain specific amino acids, the building blocks of proteins: methionine, isoleucine and valine, when consumed in excess, appear to activate certain biological pathways which, if they remain constantly ‘switched on’, could contribute to obesity, inflammation and other conditions typical of ageing.

Personalising diet and exercise

However, the results of the studies are not all consistent, and the picture becomes more complicated. Other studies suggest that a higher protein intake helps with weight loss and, particularly in older people, helps to preserve muscle mass, especially when combined with an exercise programme. It is no coincidence that the US dietary guidelines, updated just this year, have almost doubled the previous recommendations regarding protein intake, suggesting an intake of 1.2–1.6 grams of protein per kilogram of body weight per day.

According to Lamming, the key lies precisely in physical activity: athletes consume large amounts of protein without suffering any adverse metabolic effects, perhaps because regular exercise directs the protein towards the ‘building’ and maintenance of muscle, rather than towards uncontrolled cell growth.

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The key takeaway is not ‘stop eating protein’, but to eat the right amount, based on your age and, above all, how active you are. In short, this review is far from recommending a ‘one-size-fits-all’ diet; a diet should always be tailored to the individual.

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