Pharmaceuticals

Astrazeneca, profit doubled in 2023 to 6 billion

However, the rbitannic group disappointed the market with below-consensus profitability estimates.

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo

3' min read

3' min read

Profitability doubled for AstraZeneca in 2023. The British pharmaceuticals group ended the last financial year with a $6 billion profit for the year, almost double the previous year's profit, thanks to the performance of its oncology division and despite the slowdown in sales of Covid drugs (sales of the company's coronavirus vaccine last year plummeted 99%). Rrevenues increased by 3% to USD 45.8 billion (+13% excluding Covid drugs).

Earnings per share rose to $1.45 in the fourth quarter alone, below analysts' estimates, pa due to costs incurred by the group for the launch of new drugs such as Airsupra for asthma.

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The market disappointment

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Although the pharmaceutical company reported slightly better-than-expected fourth-quarter revenues, profits fell short of analysts' estimates, hurt by increased investment in research and development and price reductions for some drugs in emerging markets. Shares yesterday on the FTSE 100 fell about 2 per cent in the early stages after the announcement, while today they are recovering almost a percentage point.

Group diversification

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In the almost a decade since AstraZeneca rejected a takeover by US rival Pfizer, CEO Pascal Soriot has rebuilt the Anglo-Swedish manufacturer's pipeline, including blockbusters such as lung cancer drug Tagrisso, leukaemia drug Calquence and diabetes drug Farxiga. The group's diversification accelerated with several acquisitions in 2023 and a licensing deal in November that brought it into the booming market for anti-obesity drugs. Sales of Tagrisso grew by 9% last year, while revenues of Imfinzi, another anti-cancer drug, increased by 55% and sales of Calquence rose by 23%.

Demand for cancer drugs such as Tagrisso and Lynparza is fuelling sales growth, but there is concern about a new drug called datopotamab deruxtecan, or Dato-DXd, from a collaboration with Daiichi Sankyo. Investors await news of regulatory approval this year after mixed results in clinical trials. In addition, Astra entered the anti-obesity drug race late last year with an agreement to develop an experimental pill that is still in early testing.

Geographically, the group is also considered a benchmark for the Chinese pharmaceutical sector, given its strong presence in the region. revenues in China increased by 16% in the last quarter of 2023 to $1.38 billion. At the end of last year, the group had announced the acquisition of China's Gracell Biotechnologies for up to USD 1.2 billion, with the aim of strengthening its ambitions in the field of cell therapies. The cash deal values US-listed Gracell at $2 per share, plus a non-negotiable Contingent Value Right (Cvr) of $0.30 per common share if certain regulatory milestones are reached.

Estimates 2024

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AstraZeneca expects to increase revenues and profits this year on the back of resilient demand for its cancer and rare disease drugs, the company said on Thursday after reporting slightly lower-than-expected fourth-quarter profits. Revenue growth is estimated at 10% (at constant exchange rates), according to Chief Executive Pascal Soriot in the accounts note. Double-digit percentage growth is also expected for profits from core activities. "We expect another year of strong growth in 2024, driven by the continued adoption of our medicines in all geographies," Soriot said.

Analyst comments

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JP Morgan analysts say the strong outlook should dispel some observers' concerns about slowing growth. Other analysts, including those at Citi and Jefferies, pointed to some potential problems for 2024, including major research and development upgrades expected from the drugmaker.

"We have some long-term concerns about therapeutic diversification within the company, no matter how strong the underlying talent and science," Citi said in a note.

The forecast is solid for sales but 'just shy' for profits, suggesting a lower-than-expected margin expansion, Jefferies analysts Peter Welford and Lucy Codrington wrote in a note to clients.

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The pharmaceutical company could raise its estimates as the year progresses, according to Bloomberg Intelligence, which called the guidance conservative: "AstraZeneca's initial guidance projection for 2024 appears conservative, implying little or no progress in operating margin. The target for total sales growth in constant currency, from low double-digit to low-teens, and core eps is one of the strongest among peers, but with 2-3 new product launches expected this year, we do not think SG&A can grow in line with sales, helping margin. Adjusted EPS updates may then follow later in the year'.


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