October pink month

Breast cancer, the voice of oncologists: lower the screening age to 45

Free 'early' mammography in all regions and a sprint on healthy lifestyles: these are the indications of experts who applaud the possible increase in funds for prevention in the manoeuvre but call for criteria in line with scientific evidence

by Barbara Gobbi

5' min read

Translated by AI
Versione italiana

5' min read

Translated by AI
Versione italiana

Increasing the resources earmarked for prevention from the current meagre 5 per cent of healthcare expenditure to 6 per cent: this is one of the proposals for healthcare at the centre of the negotiations now under way on the next budget law. An instance 'blessed' and brought to the Mef by Health Minister Orazio Schillaci, an oncologist who has been repeating the mantra since the beginning of his term of office about the shot in the arm that could come if the population adopted correct lifestyles: in an ideal condition, the benefit would be a -40% reduction in cases.

Today, the reality is quite different: investments in prevention are 'Cinderella' compared to the other items of public health expenditure, which fell by 18.6% between 2022 and 2023 from 10 billion to 8 billion and 453 million, extreme regional variability, and lifestyles including smoking, alcohol consumption, and poor diet that are not improving overall, but rather see a downward alignment between northern and southern Italy. With the result, albeit in a general context of high-level treatment in the country, of one thousand cancer diagnoses per day with 390,100 new cases estimated in 2024. Numbers on which there is ample room for intervention: first of all, with greater awareness among citizens, who still do not adequately 'exploit' the chance of free tests offered by the Essential Levels of Care (LEA) for breast, uterine, and colorectal cancer. The regional scissors are wide, with the Regions in the re-entry plan bound to the Lea (on the age range for breast examinations, for example) but also, and this applies to many territories around Italy, with inadequate organisation of screening.
A reality recalled by Schillaci during the presentation of the Frecciarosa project promoted by the FS Group and the IncontraDonna Foundation with the Aiom Association of Medical Oncologists, on cancer prevention by train aimed precisely at women for "October pink month": "We must increase the percentage of funds for prevention and improve screening campaigns to achieve greater equity of care - warned the minister -: in the adherence there is still too much of a gap between North, Centre and South and this is unacceptable".

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Lifestyle sharper weapon

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Oncologists applaud the announced increase in resources in the manoeuvre. "This would be a very important signal," explains Massimo Di Maio, president-elect of Aiom. As an association, we are certainly constantly committed to diagnosis and treatment, but we are aware that prevention is the most effective weapon, as well as being the most cost-effective. An investment that will clearly have results in the medium to long term, but they will be enormous achievements. Primary prevention to reduce the incidence of the disease through correct lifestyles would bring us considerable benefits, although it is clear,' he points out, 'that a 40 per cent reduction in cancers by cutting out smoking, alcohol, bad diet and promoting a healthy diet is an ideal scenario. Certainly, however, one can aim for a net improvement even if only by convincing half of the Italian population'.

Funds to be increased

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Something has moved on the front of funds for the diagnosis of breast cancer, but it is a drop in the ocean: if the Milleproroghe decree at the beginning of the year allocated one million euros between 2025 (200,000 euros) and 2026 (800,000) to expand the age range for screening from 45 to 74 years, the waiting lists bill has seen the rejection by the Mef of a 'treasury' of 6 million euros to be invested in three years. The road, however, is mapped out by international guidelines, so much so that the EU recommends lowering the age for mammography between 45 and 49 and raising it between 70 and 74.

Extending breast tests

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Endorsing the importance of this measure, which Minister Schillaci himself defends, is Di Maio himself: 'In the face of scientific evidence confirmed by a recommendation,' he explains, 'it is not acceptable for there to be differences between regions based solely on economic criteria. Instead, today many realities are at zero while others have extended screening only partially. Ideally,' she points out, 'the age for free breast screening should start at 45 everywhere. Of course the Regions must have a say on the organisation of screening on the territory and on the modality of the invitation to the test for the citizen, but they cannot contravene scientific evidence'.

Citizens to be empowered

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Secondary prevention (with screening) makes it possible to find the disease at an earlier stage and therefore with a greater chance of recovery. On this, as the minister and the association of oncologists point out, a call to responsibility is needed: 'We often complain that the SSN fails to give everything it promises,' Di Maio emphasises, 'but in reality there are already many services available that the population does not take up. Like the screenings offered free of charge by all the regions and which are often not used. Yet as the Higher Institute of Health has recently certified, screening coverage is closely correlated with mortality reduction. Citizens must be aware of this: while it is true that Southern Italy started later and that some regions still have to perfect the modalities of the free invitation to the three tests for breast, uterine and colon cancer, it must also be reiterated that there is also a significant quota of people who do not adhere. It is a choice that is up to each one of us: an investment in health, with tests that have benefits that are immensely greater than the minimal inconvenience they cause'.

The 'weighted' benefits of prevention

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How much is cancer mortality lowered with full adherence to screening? There has not yet been a study on Italy, but the results of a US paper published in Jama Oncology are crucial. It refers to 1975-2020 data and took into account the cancer deaths prevented in the USA (5.94 million in all) over those 45 years for breast, lung, colorectal and prostate, estimating how many were due to primary prevention, how many to screening, and how many to more effective therapies. "Primary prevention and screening," Di Maio explains, "account for about 80 per cent of these avoided deaths (4.75 million), with a relative contribution of individual interventions according to the type of tumour. Three figures out of all: for breast cancer, screening accounts for 25% of the avoided deaths, while the others are attributable to therapeutic advances. In the case of the colon-rectum, for which we have a low adherence of citizens, especially in the South, screening has prevented 79% of deaths thanks to the removal of precancerous polyps or diagnosis at an earlier stage. Data from which comes a clear indication also in Italy to adhere to an absolutely non-invasive test.
Finally, the lung, and here we 'close the circle' with a reference to lifestyles: '98% of the improvement in mortality has been attributed to the reduction of smoking, since screening - which started a few years ago in Italy as well - did not have a wide diffusion initially even in the USA, while only in the last period have great therapeutic advances been recorded,' Di Maio concludes.

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