Pharmaceuticals

Roche’s Managing Director: ‘Italia is less competitive; drug trials have fallen by 30 per cent’

According to Amy VanBuskirk, the Swiss giant’s new General Manager in Italia, there is a risk of a ‘silent’ relocation. We are too slow at recruiting patients for research

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3' min read

Translated by AI
Versione italiana

3' min read

Translated by AI
Versione italiana

‘We welcome the initial signs from the Italian Government in the budget and the Consolidated Act, but the pace of reform is still too slow compared to the speed at which international capital moves. The real risk for Italia is that of a silent exodus: with every day that passes without structural decisions, major investors are choosing other hubs”: Amy VanBuskirk is the new General Manager of Roche in Italia, the Swiss giant which presented its new impact study on our country in Rome: an ‘impact’ of 718 million on GDP, involving over 1,300 Italian suppliers across 51 product sectors, 78 per cent of which are SMEs. These are significant figures, but they also reveal a substantial decline in research investment of over 30 per cent: the number of clinical trials funded by Roche has fallen from 174 in 2023, with 56.5 million invested, to 137 in 2025, with 33 million invested.

How strategic is Italia?

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We have been here for 130 years, and our Italian subsidiary was the first to be established outside Switzerland; this illustrates the strategic importance of our presence, which stems from many reasons – in particular because Italia is a hub boasting outstanding scientific expertise and skills, with robust public and private centres and highly skilled researchers who can help us bring innovation to the patient’s bedside.

Why has there been this reduction in investment in Italia?

This does not mean that there has been an actual decision to divest; the point is that, whilst Italia remains attractive to its top researchers and boasts excellent infrastructure, it has, on the other hand, become less competitive. In particular, its weakness lies in the slow pace at which clinical trials are initiated compared with other countries. The figures show that 144 days elapse between the trial being approved and the first patient being enrolled, compared, for example, with 111 days in Spain and 140 days in France and Germany. Whilst this slowness is already apparent within Europe, it is even more evident in international competition, for example with China. And this is a real shame because Italia has all the capabilities and requirements to be attractive on an international level. Italia is, however, still involved in 85 per cent of Phase III trials and 75 per cent of Phase II trials conducted globally by Roche.

What is Italia losing?

Every clinical trial within Roche is competitive: if there is a centre in another country that is quicker at recruiting patients, Italia loses the opportunity to bring research into new therapies to the country. For every two and a half days’ delay in recruitment, one patient is lost, along with an economic benefit of 37,000 euros. Overall, bureaucratic delays in setting up clinical centres have cost the country over 10,500 unrecruited patients and 180 million euros in lost healthcare benefits over three years.

How are Europe and Italia responding to global challenges: from competition with China to dealing with the US’s MFN status?

Europe sometimes turns a blind eye to the evidence, whilst at other times it tries to reason things through. The key is to ensure that pharmaceutical innovation is not seen merely as a cost but as an investment, as is the case in China, where public policy recognises this value. In Italia, we are seeing positive signs in this regard, but more needs to be done, with the public and private sectors working together. We need comprehensive and structural reforms that tackle the root causes of the problems

You are the second-largest contributors to the payback scheme, having paid 178 million in 2025. How significant is this mechanism in your investments?

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I understand the pressure on countries’ healthcare budgets, including Italia’s. But here too, a change of direction is needed – such as, for example, transforming the payback from a penalty into an incentive, perhaps by reinvesting the revenue collected into research or highly specialised employment. In this regard, the idea set out in the budget to reward those who invest in Italia with lower payback rates is also a step in the right direction.

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