The research

Hip and knee replacements: even when they work well, they ‘age’ inside the body

In fact, from the very day after orthopaedic surgery, hip and knee prostheses engage in a sort of chemical and mechanical war with the body that hosts them – a war that never ends

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3' min read

Translated by AI
Versione italiana

3' min read

Translated by AI
Versione italiana

When you look at it before implantation, a hip or knee prosthesis appears to be an inert piece of metal which, as such, might remain unchanged for decades inside the body. But this is not the case. In fact, from the very day after orthopaedic surgery, hip and knee prostheses engage in a sort of chemical and mechanical battle with the body that hosts them – a battle that never stops, not even for a moment, not even at night.

This leads to a series of consequences that contribute to the wear and tear of the prosthesis and which, at a certain point, make a repeat operation necessary. But what are the processes that contribute most to the ageing of orthopaedic prostheses? This was the question posed by a study published in npj Materials Degradation (part of the Nature group), conducted by Western University and the London Health Sciences Centre Research Institute (LHSCRI) in Canada, which analysed over 240 hip and knee prosthetic components removed from patients during revision surgery.

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The culprit is ‘tribocorrosion’

The laboratory where the study was conducted, headed by Matthew Teeter, a professor at the Schulich School of Medicine & Dentistry, houses Canada’s largest collection of hip, knee, shoulder and dental prostheses removed following failure.

A veritable living archive of the biomechanics of the human body, which researchers cross-reference with similar data collection networks operating in Australia, the United States and Slovenia. “Having a prosthesis in your body literally changes your body’s chemistry,” explains Yolanda Hedberg, professor of chemistry at Western University. “You may not feel any pain or other symptoms, but your body’s chemistry is constantly changing.”

The main culprit behind this damage has a rather ominous technical name: it is tribocorrosion (‘tribology’ is the study of friction, wear and lubrication), which occurs when movement and chemical reactions act upon the same surface at the same time, thereby multiplying the damage compared to what either would cause on its own.

How dentures can be damaged

This mechanism, which the research team has characterised using optical and scanning electron microscopy combined with spectroscopy, causes cyclical damage to the prosthesis.

Modern prostheses are made from metals such as titanium, protected by an extremely thin layer of surface oxide that isolates them from the surrounding biological fluids. But with every single step the patient takes, this protective shield is scraped away and destroyed, at least temporarily. “Mechanical wear destroys the surface oxide layer,” explains Hedberg, “in a matter of milliseconds. Every step taken by the patient temporarily damages this protection, and this immediately triggers a massive chemical response.”

Once at rest, the oxide reforms, but this process is ready to start all over again as soon as the patient starts walking again, thus creating an endless cycle of breakdown and repair, which takes place invisibly and silently, but which is repeated thousands of times a day in the joints of millions of people around the world.

Proteins further complicate the picture. As soon as the implant is inserted, proteins present in bodily fluids coat its surface, transforming it into a sort of ‘code’ that the body reads before deciding how to respond. “The proteins that adhere to the surface of the prosthesis determine the body’s reaction,” continues Hedberg. “They are a ‘language’, the way in which the body communicates.” And, depending on the predominant type of protein – and therefore the ‘language’ spoken – the implant may integrate well with the bone or, conversely, trigger an inflammatory response or, in the worst-case scenario, lead to bacterial colonisation.

Wear and tear on an industrial gear

In many respects, the corrosion and wear observed in removable dentures resemble the deterioration of an industrial gear. But in the human body, everything is more complex because the surface is exposed to a constantly changing mix of mechanical stress, bodily chemicals, proteins and inflammatory responses. The body’s ‘industrial system’ walks, climbs stairs or dances at a friend’s birthday party every day. The study also identified certain patient-related factors that appear to exacerbate the extent of the damage: excessive body weight and longer surgical times were found to be associated with higher damage scores. The presence of an infection at the time of surgery is also associated with greater surface deterioration in specific areas of the hip prosthesis.

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“Every patient is different. The removed prostheses provide us with a real-life record of how the materials behave after having been inside the body for years,” emphasises Hedberg. “However, this does not mean that people should be afraid of undergoing a hip replacement or knee replacement operation. In most cases, these procedures significantly improve quality of life and health in the long term. Our work simply aims to ensure that more and more people can benefit from them in the future as well.”

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