The Basel Group

Horber (Novartis): ‘We are still investing, but Italia and Europe are losing ground’

The President of International in Rome to discuss competitiveness: a further 63 million earmarked for research at the Ivrea plant; bureaucracy and regulations are weighing on the future

FILE PHOTO: The company's logo is seen at the new cell and gene therapy factory of Swiss drugmaker Novartis in Stein, Switzerland, November 28, 2019. REUTERS/Arnd Wiegmann/File Photo REUTERS

3' min read

Translated by AI
Versione italiana

3' min read

Translated by AI
Versione italiana

Patrick Horber is the International President of Novartis and will be in Rome tomorrow, where he will meet with no fewer than four Italian ministers – Schillaci, Tajani, Pichetto Fratin and Urso – to discuss how to ‘strengthen the competitiveness of the pharmaceutical sector in Italia and Europe’. This event – the Health & Innovation Forum, which will also be attended by Farmindustria President Marcello Cattani – was organised by the Basel-based group to discuss the potential of the Italian system, as well as the obstacles holding it back. “Italia is one of Novartis’s top ten markets, and we have around 1,900 employees and approximately 200 active clinical trials. It is also a major hub for innovation. Today, Ivrea,’ explains Horber, ‘is one of only four Novartis sites worldwide dedicated to the production of radioligand therapies, which are highly innovative for cancer patients globally. Ivrea is a concrete example of how investment in the life sciences can improve patient health outcomes, whilst creating skilled jobs and supporting the region’s economic growth.”

Will you be making further investments in research in Italia?

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Alongside production and the €150 million already announced for research and development, we are investing a further €63 million in Technical Research and Development in Ivrea up to 2028. Italia possesses the talent, scientific expertise and industrial capacity to contribute to the development of next-generation technologies. To fully realise this potential, it is important to continue strengthening the national innovation ecosystem, fostering a stable, competitive and research-oriented environment. The forthcoming Consolidated Act represents a significant opportunity to establish clear and sustainable long-term rules capable of promoting innovation whilst, at the same time, improving patients’ timely access to new treatments.

Competition is intensifying, with the US and China gaining ground. What are Europe’s main shortcomings?

Europe has lost significant ground. The main shortcomings relate to the slow pace at which patients gain access to new medicines, a regulatory framework that is not keeping pace with scientific progress, and a focus that is centred more on short-term costs than on the overall value of innovation. The European Union’s share of global clinical trials has fallen by around 50 per cent over the last decade. As a result, around 60,000 European patients have been denied access to clinical trials that could have taken place in Europe.

Is the MFN clause promoted by Trump delaying the arrival of innovative medicines in Europe?

Access to innovative medicines has long been a critical issue in Europe. Historically, only around half of the medicines available in the United States reach European patients, and in Italia, access is granted on average around 441 days after European approval. Our aim is always to bring our innovative medicines to patients who can benefit from them. Predictable conditions that are conducive to innovation are essential to support broad and sustainable access to innovative medicines in Europe. When these conditions are not in place in a country, availability may be delayed or limited, affecting patients’ access. We recognise the pressures faced by public decision-makers and payers, and we aim to be collaborative partners.

How can Italia become more competitive and attract more investment?

Innovation is drawn to contexts where it is recognised, valued and supported. Italia can enhance its appeal by creating conditions that properly value innovation and support patient access to it. In Italia, for example, the payback period can reduce the effective value of medicines in ways that are difficult to predict and plan for. This weakens the incentives for launching new treatments and for investment, with potential repercussions for patient access.

And how can we make the country more attractive for research into new medicines, and what are the main obstacles today?

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Italia has outstanding researchers and treatment centres, but slow and complex processes are driving clinical research to other countries. Italy ranks fourth in Europe for active clinical trials, whilst Spain has risen to first place: streamlining procedures is essential to attract more investment in R&D. The opportunity is significant: closing the gap with the United States and China could generate €53 billion and 82,000 jobs in Europe from clinical trials. We also need to prepare healthcare systems to provide access to new therapies. Radioligand therapies illustrate this: today, 47 centres in Italia are able to administer them, but regional disparities remain, particularly in Piedmont and, above all, in central and southern Italy – in Tuscany, Lazio and Puglia. Italia has the capacity to play a leading role. We want to collaborate with partners in the healthcare ecosystem to help create the conditions for innovation to flourish, for the benefit of patients, the economy and society.

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