Stem cells: wireless stimulation to regenerate the spinal cord

The aim is to regenerate spinal cord injuries. This is achieved through the electrical stimulation of stem cells wirelessly, following a path that could open the door to other therapeutic scenarios. Developing this technique, which is considered innovative, is a group of researchers from ENEA as part of the European Riseup project in which La Sapienza University of Rome and the company Rise Technology are participating in Italy.

In particular, as emphasised by the research agency, 'a device has been developed that is able to stimulate stem cells transplanted into the injured spinal cord, thanks to an innovative electrode whose electrical impulses promote their differentiation into neurons'.

'We have developed a totally biocompatible device,' explains Claudia Consales, ENEA researcher and head of the Sustainability department, 'capable of delivering wireless electrical impulses to transplant and modify stem cells directly into damaged spinal cord tissue.

The device consists of a 3D-printed capsule, 'designed to integrate the electronic part, which in turn is connected to a completely flexible electrode' that can easily adapt to any body shape. 'This is an approach that not only allows for a less invasive surgery,' adds the researcher, 'but also improves the integration of stem cells and allows the inflammatory response to be reduced.

A result considered by the researchers to be 'important' and capable of opening up 'promising scenarios for new fields of application of electrical impulses'. On the horizon is a use both in regenerative medicine and in diseases in which inflammation contributes to disease progression.