Iss Bulletin

West Nile: 32 confirmed cases, how the infection map is changing

Two deaths confirmed, one in Lazio and one in Piedmont. Palamara: 80% of cases are asymptomatic, more serious consequences for frail people

by Ernesto Diffidenti

Operatori della Asl  di Caserta  impegnati nell'installazione di trappole per le zanzare Culex responsabili del contagio sull'uomo del West Nile, Caseta, 24 luglio 2025 ANSA / CIRO FUSCO

3' min read

3' min read

Since the beginning of the year on 23 July, there have been 32 confirmed cases of West Nile virus infection in humans in Italy. Twenty-one of the 32 cases were reported by the Lazio Region, all in the province of Latina epicentre of an initial outbreak. It is the Istituto Superiore di Sanità (Higher Institute of Health) that has updated the growing number of cases, pointing out that of the 32 cases, 23 manifested themselves in the neuro-invasive form (2 Piedmont, 2 Veneto, 1 Emilia-Romagna, 15 Lazio, 3 Campania), 1 asymptomatic case identified in a blood donor (1 Veneto) and 6 cases of fever (2 Veneto, 4 Lazio). Among the confirmed cases, 2 deaths were reported (one in Piedmont and one in Lazio).

Epidemiological trend in line with previous years

"From a numerical point of view," explains the Iss, "the epidemiological trend at the moment is in line with that of previous years, while the spatial distribution appears quite different. "All measures are in place," emphasises Anna Teresa Palamara, who heads the Iss's Infectious Diseases department, "including those to protect transplants and transfusions. We must remember that 80% of cases of West Nile infection are asymptomatic, while the risk of serious consequences is greater for the most fragile people".

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The disease is not transmitted from person to person. "The advice," Palamara continues, "is therefore to protect yourself as much as possible from contact with mosquitoes, the vectors of the virus, and to contact your doctor if you have symptoms such as fever above 38°C, especially if accompanied by a rash. For doctors, the indication is to consider the possibility of West Nile infection in the presence of compatible symptoms and proceed to laboratory diagnosis'.

Lazio: Latina convenes Conference of Mayors for health

In Lazio, with twelve new cases of West Nile detected, there are 20 people who have contracted the virus, 21 counting the deceased woman, all in Latina and its province. "We are in daily contact with the ASL," says the first citizen Matilde Celentano, "and the administration is moving promptly according to the infectious developments. I have convened the Conference of Mayors on Health with the subject 'Communications on the prevention of the West Nile virus', which will take place on Tuesday 29 July. It will be an opportunity to discuss with the other first citizens and to coordinate the actions to be carried out in the territories'.

Campania: high guard but no psychosis

From Campania comes the appeal by the coordinator of the Regional Transplant Centre, Pierino Di Silverio, to avoid alarmism. 'Understandably,' he emphasises, 'we are receiving many requests for information from the families of patients who have recently undergone transplants and from those waiting for an organ. It must be made clear that West Nile will in no way compromise transplant activity, nor will it put patients at risk'. For Di Silverio, all necessary measures to protect patients have been activated and 'we are in constant contact with the health authorities. It is right to keep our guard up, but it is essential that there is no psychosis'.

Veneto and Friuli Venezia Giulia: moderate virus circulation

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The West Nile virus is circulating in a moderate form in mosquitoes in Veneto and Friuli Venezia Giulia. Initial analyses carried out by the Laboratory of Sanitary Entomology of the Experimental Zooprophylactic Institute of the Venezie reveal 12 positive mosquito pools out of 1,233 analysed (70,363 mosquitoes) with an infection rate of 1%. For the institute's director-general, Antonia Ricci, "even though the circulation of the West Nile virus is lower than in previous years and the situation is currently within the normal range, it is essential to maintain a high level of attention on mosquito monitoring. The early identification of the virus in mosquitoes allows the rapid activation of the health control system at all levels and guarantees the safety of transfusions and transplants in humans. The integrated surveillance system set up in Veneto that includes mosquitoes, birds, horses and humans allows us to experience the One Health approach at first hand'.

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